Ammonium Chloride → 4-(3-Amino-5-chloro-phenoxymethyl)-N-methyl-benzamide

HRID 2197949Notes

Reaction equation

HRID 2197949 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[C:18]([N+:20]([O-])=O)[CH:19]=1)[O:5][CH2:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([NH:13][CH3:14])=[O:12])=[CH:9][CH:8]=1.[NH4+].[Cl-]>[Fe]>[NH2:20][C:18]1[CH:17]=[C:4]([CH:3]=[C:2]([Cl:1])[CH:19]=1)[O:5][CH2:6][C:7]1[CH:16]=[CH:15][C:10]([C:11]([NH:13][CH3:14])=[O:12])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 684568784-(3-Chloro-5-nitro-phenoxymethyl)-N-methyl-benzamide

Product 1

HCID 684587354-(3-Amino-5-chloro-phenoxymethyl)-N-methyl-benzamide

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The product from Example 195c was reduced with Fe and NH4Cl following the procedure from Example 237E to give the title compound.

Sources & evidence

ORD record
ord-d0f1c1cc4ef940ed8a4909ae7aa0e231
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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