Ammonium Chloride → 3-(4-Bromo-benzyloxy)-5-chloro-phenylamine

HRID 2197952Notes

Reaction equation

HRID 2197952 reaction equation

[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[C:10]([Cl:17])[CH:9]=2)=[CH:4][CH:3]=1.[NH4+].[Cl-]>[Fe]>[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[C:10]([Cl:17])[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 25517Ammonium Chloride

HCID 684604931-(4-Bromo-benzyloxy)-3-chloro-5-nitro-benzene

Product 1

HCID 684611983-(4-Bromo-benzyloxy)-5-chloro-phenylamine

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The product from Example 196a was reduced with Fe and NH4Cl following the procedure from Example 237E to give the title compound.

Sources & evidence

ORD record: ord-b97f8bfcded74893b808058cae79baa5
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338605B2

Reaction notes

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