HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197957Generated: November 2, 2026
4-Chloro-3-nitrotoluene → 3-(4-Methyl-2-nitro-phenylsulfanyl)-phenylamine
https://huagongshe.com/reaction/2197957
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-nitrotoluene | HCID 6976 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Aminothiophenol | HCID 31577 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(4-Methyl-2-nitro-phenylsulfanyl)-phenylamine | HCID 68457917 | 33% |
Reaction Steps
The title compound was prepared from 3-Amino-benzenethiol (5.034 g, 40.21 mmol), 1-Chloro-4-methyl-2-nitro-benzene (4.600 g, 26.81 mmol) and K2CO3 (6.484 g, 46.92 mmol) dissolved in DMF and heated to 100° C. for 16 hrs. At this time the reaction mixture was cooled to room temperature and diluted with water, extracted with ethyl acetate. Dried over Na2SO4, filtered and concentrated under vacuum giving the title compound (2.3 g, 32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338605B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-82e0ea37af804560abe394a97d72b584 |
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| Source note | uspto-grants-2012_12 |
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