2-Nitro-4-trifluoromethyl-biphenyl → 4-(Trifluoromethyl)[1,1′-biphenyl]-2-amine

HRID 2197979Notes

Reaction equation

HRID 2197979 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([O-])=O.C1COCC1.CCO>C(O)C>[F:11][C:10]([F:12])([F:13])[C:8]1[CH:7]=[CH:6][C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([NH2:1])[CH:9]=1

Participants

4

Reactant 2

HCID 113001192-Nitro-4-trifluoromethyl-biphenylHCID 21873804Tetrahydrofuran ethanol

Product 1

HCID 117365264-(Trifluoromethyl)[1,1′-biphenyl]-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from Example 218a was reacted as described in Example 212c substituting 3:1 THF/EtOH (4 mL) for ethanol to give the title amine in quantitative yield.

Sources & evidence

ORD record
ord-ea0ef3ede4a747fda7af98af3784dd82
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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