4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene → HCID 67022225, compound

HRID 2198024Notes

Reaction equation

HRID 2198024 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[NH:13]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([N:13]2[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14]2)=[CH:3][C:4]=1[C:9]([F:12])([F:11])[F:10]

Participants

3

Reactant 2

HCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotolueneHCID 53428732Ethyl 3-(pyrrolidin-3-yl)propanoate

Product 1

HCID 67022225HCID 67022225, compoundYield 61%

Procedure

The title compound (5.0 g, yield 61%) was obtained from 4-bromo-1-chloro-2-(trifluoromethyl)benzene and ethyl 3-(pyrrolidin-3-yl)propanoate obtained in Reference Example 12 by a method similar to that in Reference Example 1.

Sources & evidence

ORD record
ord-0216687dcc0048598625a2ece54bc722
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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