4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene → 1-[4-Chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-ol

HRID 2198030Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.[OH:13][CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([N:16]2[CH2:17][CH2:18][CH:14]([OH:13])[CH2:15]2)=[CH:3][C:4]=1[C:9]([F:12])([F:11])[F:10]

Participants

Reactant 2

HCID 679594-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene

HCID 982104-Hydroxypyrrolidine

Product 1

HCID 670220301-[4-Chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-olYield 90%

Procedure

The title compound (8.56 g, yield 90%) was obtained from bromo-4-chloro-3-(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.

Sources & evidence

ORD record: ord-b3e0fc83d92741f1b25a62238aaf9650
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338622B2

Reaction notes

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