HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene → 1-[4-Chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene | HCID 67959 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Product | 1-[4-Chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-ol | HCID 67022030 | 90% |
Reaction Steps
The title compound (8.56 g, yield 90%) was obtained from bromo-4-chloro-3-(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338622B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b3e0fc83d92741f1b25a62238aaf9650 |
| Source note | uspto-grants-2012_12 |