4-Hydroxypyrrolidine → HCID 67022229, compound

HRID 2198031Notes

Reaction equation

HRID 2198031 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:12]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13]1.BrC1C=CC=C(C(F)(F)F)C=1Cl.OC1CCNC1>>[F:11][C:8]([F:9])([F:10])[C:7]1[CH:2]=[C:3]([N:12]2[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13]2)[CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 982104-HydroxypyrrolidineHCID 32831733-Bromo-2-chlorobenzotrifluorideHCID 67022294HCID 67022294, compound

Product 1

HCID 67022229HCID 67022229, compound

Procedure

A mixture of 1-[2-chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-ol and 1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-ol was obtained as a brown oil (8.08 g, yield 90%) from 1-bromo-2-chloro-3-(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1. This was used for the next reaction without performing further purification.

Sources & evidence

ORD record
ord-27514de2d76843d6b6ae9bf6058503de
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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