HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxypyrrolidine → HCID 67022229, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | 3-Bromo-2-chlorobenzotrifluoride | HCID 3283173 | — |
| Reactant | HCID 67022294 | HCID 67022294 | — |
| Product | HCID 67022229 | HCID 67022229 | — |
Reaction Steps
A mixture of 1-[2-chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-ol and 1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-ol was obtained as a brown oil (8.08 g, yield 90%) from 1-bromo-2-chloro-3-(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1. This was used for the next reaction without performing further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338622B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-27514de2d76843d6b6ae9bf6058503de |
| Source note | uspto-grants-2012_12 |