HCID 67022229, compound → HCID 87239791, compound

HRID 2198032Notes

Reaction equation

HRID 2198032 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][CH:12]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[C:18]=3Cl)[CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.ClC1C(C(F)(F)F)=CC=CC=1N1CCC(O)C1.FC(F)(F)C1C=C(N2CCC(O)C2)C=CC=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([O:11][CH:12]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=3)[CH2:13]2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 67022229HCID 67022229, compoundHCID 67022294HCID 67022294, compoundHCID 87239830HCID 87239830, compound

Product 1

HCID 87239791HCID 87239791, compound

Procedure

A mixture of 1-[2-chloro-3-(trifluoromethyl)phenyl]pyrrolidin 3-yl 4-methylbenzenesulfonate and 1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl 4-methylbenzenesulfonate was obtained as white crystals (3.35 g, yield 69%) from a mixture of 1-[2-chloro-3-(trifluoromethyl)phenyl]pyrrolidin-3-ol and 1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-ol obtained in Reference Example 26 by a method similar to that in Reference Example 24. This was used for the next reaction without performing further purification.

Sources & evidence

ORD record
ord-214a2810429a44248d17e5878927a2b6
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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