Benzene, 1-bromo-2-(trifluoromethyl)- → 1-[2-(Trifluoromethyl)phenyl]pyrrolidin-3-ol

HRID 2198038Notes

Reaction equation

HRID 2198038 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1Br.[OH:12][CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1>>[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:15]1[CH2:16][CH2:17][CH:13]([OH:12])[CH2:14]1

Participants

3

Reactant 2

HCID 9806Benzene, 1-bromo-2-(trifluoromethyl)-HCID 982104-Hydroxypyrrolidine

Product 1

HCID 629179911-[2-(Trifluoromethyl)phenyl]pyrrolidin-3-olYield 67%

Procedure

The title compound (3.72 g, yield 67%) was obtained from 2-(trifluoromethyl)phenyl bromide and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.

Sources & evidence

ORD record
ord-ea6b6f0dff9f4ba6b822ae9bf5837e6a
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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