HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-bromo-2-(trifluoromethyl)- → 1-[2-(Trifluoromethyl)phenyl]pyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-bromo-2-(trifluoromethyl)- | HCID 9806 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Product | 1-[2-(Trifluoromethyl)phenyl]pyrrolidin-3-ol | HCID 62917991 | 67% |
Reaction Steps
The title compound (3.72 g, yield 67%) was obtained from 2-(trifluoromethyl)phenyl bromide and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338622B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ea6b6f0dff9f4ba6b822ae9bf5837e6a |
| Source note | uspto-grants-2012_12 |