Hydrochloric Acid → (S)-1-(5-methanesulfonyl-furan-2-yl)-propylamine hydrochloride

HRID 2198140Notes

Reaction equation

HRID 2198140 reaction equation
[CH3:1][S:2]([C:5]1[O:9][C:8]([C@@H:10]([NH:13][S@@](C(C)(C)C)=O)[CH2:11][CH3:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:20].O1CCOCC1>CO>[ClH:20].[CH3:1][S:2]([C:5]1[O:9][C:8]([C@@H:10]([NH2:13])[CH2:11][CH3:12])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59278508(R)-2-methyl-propane-2-sulfinic acid [(S)-1-(5-methanesulfonyl-furan-2-yl)-propyl]amide

Product 1

HCID 66727537(S)-1-(5-methanesulfonyl-furan-2-yl)-propylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (R)-2-methyl-propane-2-sulfinic acid [(S)-1-(5-methanesulfonyl-furan-2-yl)-propyl]-amide (0.530 g, 1.72 mmol) in methanol (5 mL) was added 4 N HCl in dioxane (2 mL, 8 mmol). After 1 hour, the mixture was concentrated in vacuo to afford (S)-1-(5-methanesulfonyl-furan-2-yl)-propylamine hydrochloride.

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-d2d462e653984474b3faedc0d9692c6d
Source dataset
uspto-grants-2012_12
Patent number
US08338610B2

Reaction notes

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