Hydrochloric Acid → 1-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

HRID 2198190Notes

Reaction equation

HRID 2198190 reaction equation
[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH:8]S(C(C)(C)C)=O)[O:4][N:3]=1.[ClH:15].O1CCOCC1>CO>[ClH:15].[Br:1][C:2]1[CH:6]=[C:5]([CH2:7][NH2:8])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727644HCID 66727644, compound

Product 1

HCID 212922721-(3-Bromo-1,2-oxazol-5-yl)methanamine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid (3-bromo-isoxazol-5-ylmethyl)-amide (128 mg, 0.455 mmol) in MeOH (5 mL) was added a 4 M solution of HCl in dioxane (0.350 mL, 1.40 mmol) dropwise. After 2 hours and 10 minutes, the reaction mixture was concentrated in vacuo to afford the title compound which was used without further purification.

Workup

  1. concentration10 minutes, the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-091cc70a435a467da2271ca2eb14866d
Source dataset
uspto-grants-2012_12
Patent number
US08338610B2

Reaction notes

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