Hydrochloric Acid → HCID 66727435, compound

HRID 2198247Notes

Reaction equation

HRID 2198247 reaction equation
[CH3:1][S:2]([C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:14]S(C(C)(C)C)=O)[CH2:12][CH3:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:21].O1CCOCC1>CO>[ClH:21].[CH3:1][S:2]([C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH2:14])[CH2:12][CH3:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727572HCID 66727572, compound

Product 1

HCID 66727435HCID 66727435, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(6-methanesulfonyl-pyridin-3-yl)-propyl]-amide (50.0 g, 157.0 mmol) in methanol (500 mL) was added a 4 N solution of HCl in dioxane (40.0 mL, 160.0 mmol). After 1 hour, the mixture was concentrated to near dryness (about 40 mL) and the resulting mixture was diluted with ether (500 mL) to afford the title compound.

Workup

  1. concentrationthe mixture was concentrated to near dryness (about 40 mL)
  2. additionthe resulting mixture was diluted with ether (500 mL)

Sources & evidence

ORD record
ord-030e20964c2c44058b895ffbfd363841
Source dataset
uspto-grants-2012_12
Patent number
US08338610B2

Reaction notes

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