Ethylamine → HCID 68909733, compound

HRID 2198254Notes

Reaction equation

[CH3:1][C:2]1([CH3:24])[C:4]([CH3:6])([CH3:5])[CH:3]1[C:7]([NH:9][C:10]1[S:18][C:13]2[CH2:14][O:15][CH2:16][CH2:17][C:12]=2[C:11]=1[C:19]([O:21]CC)=O)=[O:8].[CH2:25]([NH2:27])[CH3:26]>>[CH2:25]([NH:27][C:19]([C:11]1[C:12]2[CH2:17][CH2:16][O:15][CH2:14][C:13]=2[S:18][C:10]=1[NH:9][C:7]([CH:3]1[C:4]([CH3:5])([CH3:6])[C:2]1([CH3:1])[CH3:24])=[O:8])=[O:21])[CH3:26]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 68904499HCID 68904499, compound

Product 1

HCID 68909733HCID 68909733, compound

Procedure

The product of Example 10B and ethylamine were processed as in Examples 29A and Example 29B to afford the title compound. 1H NMR (300 MHz, CDCl3) δ ppm 1.18 (s, 1H), 1.21 (s, 6H), 1.26 (t, J=7.3 Hz, 3H), 1.32 (s, 6H), 2.77-2.83 (m, 2H), 3.41-3.55 (m, 2H), 3.98 (t, J=5.3 Hz, 2H), 4.71 (t, J=1.7 Hz, 2H), 5.70-5.82 (m, 1H), 12.02 (s, 1H); MS (DCI/NH3) m/z 352 (M+H)+; anal. calculated for C18H26N2O3S: C, 61.69; H, 7.48; N, 7.99. Found: C, 61.58; H, 7.39; N, 7.94.

Sources & evidence

ORD record: ord-d453817206534cba9ba2cef655c8fe83
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338623B2

Reaction notes

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