Ammonia → HCID 68908356, compound

HRID 2198270Notes

Reaction equation

HRID 2198270 reaction equation
[C:1]([C:5]1[S:9][C:8]([NH:10][C:11]([C:13]23[CH2:20][CH:19]4[CH2:21][CH:15]([CH2:16][CH:17]2[CH2:18]4)[CH2:14]3)=[O:12])=[C:7]([C:22]([OH:24])=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N.Cl.[NH:27]1[CH2:30][CH2:29][CH2:28]1>>[N:27]1([C:22]([C:7]2[CH:6]=[C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])[S:9][C:8]=2[NH:10][C:11]([C:13]23[CH2:20][CH:19]4[CH2:21][CH:15]([CH2:16][CH:17]2[CH2:18]4)[CH2:14]3)=[O:12])=[O:24])[CH2:30][CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 12308726Azetidine hydrochlorideHCID 68910107HCID 68910107, compound

Product 1

HCID 68908356HCID 68908356, compound

Procedure

The title compound was prepared as described in Example 166C from Example 269B and azetidine hydrochloride. 1H NMR (300 MHz, CDCl3) δ ppm 1.35 (s, 9H), 1.66 (dd, J=10.9, 2.7 Hz, 4H), 1.84-1.98 (m, 4H), 2.30-2.45 (m, 4H), 2.77 (t, J=6.6 Hz, 1H), 4.36 (t, J=7.6 Hz, 4H), 6.65 (s, 1H), 12.31 (s, 1H); MS (DCI/NH3) m/z 387 (M+H)+.

Sources & evidence

ORD record
ord-c246b6cbe82a464ea4229312a8b85488
Source dataset
uspto-grants-2012_12
Patent number
US08338623B2

Reaction notes

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