Dichloromethane → Diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride

HRID 21983Notes

Reaction equation

HRID 21983 reaction equation
C(OC([NH:8][CH:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([C:33]([OH:35])=[O:34])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)(C)(C)C.C(Cl)[Cl:37]>>[ClH:37].[NH2:8][CH:9]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]([C:33]([OH:35])=[O:34])[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 19930832Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate

Product 1

HCID 19930814Diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride

Procedure

Diethyl 2-t-butoxycarbonylamino-13-carboxy-1,14-tetradecanedicarboxylate (3.98 g, 8.40 mmol) is dissolved in methylene chloride (150.0 mL), and hydrogen chloride gas is bubbled through the solution for 15 minutes. The sealed reaction is stirred for 2.5 hours, and then the solvent is evaporated to give diethyl 2-amino-13-carboxy-1,14-tetradecanedicarboxylate hydrochloride.

Workup

  1. customhydrogen chloride gas is bubbled through the solution for 15 minutes
  2. customThe sealed reaction
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-7ec1e5eaddb34ae79356893060a4661b
Source dataset
uspto-grants-1995_06
Patent number
US05426103

Reaction notes

Loading…