Thionyl Chloride → HCID 20520138, compound

HRID 2198490Notes

Reaction equation

HRID 2198490 reaction equation
Cl.ClC[C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[C:6]([NH:13][C:14]2[C:23]3[C:18](=[C:19]([C:24]([F:27])([F:26])[F:25])[CH:20]=[CH:21][CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH:5]=1.[Cl:28]C1C2C(=C(C(F)(F)F)C=CC=2)N=CC=1.NC1C=C(Cl)C=CC=1C(O)=O.S(Cl)(Cl)=O.[NH2:58][CH:59]1[CH2:64][CH2:63][CH2:62][N:61]([CH2:65][CH2:66][CH2:67][CH3:68])[CH2:60]1>>[CH2:65]([N:61]1[CH2:62][CH2:63][CH2:64][CH:59]([NH:58][C:8](=[O:9])[C:7]2[CH:11]=[CH:12][C:4]([Cl:28])=[CH:5][C:6]=2[NH:13][C:14]2[C:23]3[C:18](=[C:19]([C:24]([F:27])([F:26])[F:25])[CH:20]=[CH:21][CH:22]=3)[N:17]=[CH:16][CH:15]=2)[CH2:60]1)[CH2:66][CH2:67][CH3:68]

Participants

6

Reactant 5

HCID 24386Thionyl ChlorideHCID 666462-Amino-4-chlorobenzoic acidHCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 20520129HCID 20520129, compoundHCID 20520134HCID 20520134, compound

Product 1

HCID 20520138HCID 20520138, compound

Procedure

4-Chloromethyl-2-(8-trifluoromethyl-4-quinolylamino)benzoyl chloride hydrochloride prepared by reaction of 4-chloro-8-trifluoromethylquinoline with 2-amino-4-chlorobenzoic acid and treatment of the reaction product with thionyl chloride, is reacted with 3-amino-1-butylpiperidine to form the title compound.

Sources & evidence

ORD record
ord-7b2870ad3dcb4bb6b21827ef7af6684e
Source dataset
uspto-grants-1982_11
Patent number
US04357333

Reaction notes

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