HRID2198491

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24386

Thionyl chloride

Cl2OS

HCID78101

2-Amino-3-methylbenzoic acid

C8H9NO2

HCID90262

4-Chloro-8-(trifluoromethyl)quinoline

C10H5ClF3N

结构：Cc1cccc(C(=O)Cl)c1Nc1ccnc2c(C(F)(F)F)cccc12.Cl

HCID20520130

未命名化合物

HCID20520150

未命名化合物

PRODUCTS

生成物

结构：CCCN(CCC)CCCCN(CCC)C(=O)c1cccc(C)c1Nc1ccnc2c(C(F)(F)F)cccc12

HCID20520120

未命名化合物

PROCEDURE

实验过程

3-Methyl-2-(8-trifluoromethyl-4-quinolylamino)benzoyl chloride hydrochloride prepared by the reaction of 4-chloro-8-trifluoromethylquinoline with 2-amino-3-methylbenzoic acid and treatment of the reaction product with thionyl chloride, is reacted with 1-dipropylamino-4-propylaminobutane to afford the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0f1a37954e8e4436a0cc07408d0619cc
来源数据集: uspto-grants-1982_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04357333
来源说明: uspto-grants-1982_11

反应 SMILES

Cl.[CH3:2][C:3]1[C:4]([NH:12][C:13]2[C:22]3[C:17](=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15][CH:14]=2)=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].ClC1C2C(=C(C(F)(F)F)C=CC=2)N=CC=1.NC1C(C)=CC=CC=1C(O)=O.S(Cl)(Cl)=O.[CH2:57]([N:60]([CH2:69][CH2:70][CH3:71])[CH2:61][CH2:62][CH2:63][CH2:64][NH:65][CH2:66][CH2:67][CH3:68])[CH2:58][CH3:59]>>[CH2:69]([N:60]([CH2:57][CH2:58][CH3:59])[CH2:61][CH2:62][CH2:63][CH2:64][N:65]([CH2:66][CH2:67][CH3:68])[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([CH3:2])[C:4]=1[NH:12][C:13]1[C:22]2[C:17](=[C:18]([C:23]([F:26])([F:24])[F:25])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1)[CH2:70][CH3:71]