(Z)-2-(2-Tritylaminothiazol-4-yl)-2-methoxyiminoacetic acid → HCID 53835278, compound

HRID 2198535Notes

Reaction equation

HRID 2198535 reaction equation
C1(C)C=C(C)C=C(C)C=1S(O[NH2:13])(=O)=O.[C:15]([NH:34][C:35]1[S:36][CH:37]=[C:38]([C:40](=[N:44][O:45][CH3:46])[C:41]([OH:43])=[O:42])[N:39]=1)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(Cl)Cl>[C:15]([N:34]=[C:35]1[N:39]([NH2:13])[C:38]([C:40](=[N:44][O:45][CH3:46])[C:41]([OH:43])=[O:42])=[CH:37][S:36]1)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 2724510(Z)-2-(2-Tritylaminothiazol-4-yl)-2-methoxyiminoacetic acidHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 53835278HCID 53835278, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

O-mesitylenesulfonylhydroxylamine (1.3 g.) was added at room temperature to a stirred suspension of 2-(2-tritylamino-4-thiazolyl)-2-methoxyimino acetic acid (2.15 g) in methylene chloride (40 ml), thus giving in a few minutes the complete dissolution of the reaction mixture. Stirring was maintained for 18 hours, during which time the mesitylenesulfonic salt of the title compound slowly separates as a white solid. The product was filtered and washed with ethyl ether, thus giving 2.98 g (92%) of 2-(2-tritylimino-3-amino-4-thiazolinyl)-2-methoxyimino acetic acid, mesitylene sulfonate, m.p.=161°-163° dec.

Workup

  1. customthus giving in a few minutes
  2. dissolutionthe complete dissolution of the reaction mixture

Sources & evidence

ORD record
ord-3fe05d15a8214a15abc4156f3ed42cbf
Source dataset
uspto-grants-1982_11
Patent number
US04358448

Reaction notes

Loading…