Sodium Chloride → 2,5,6,6-Tetramethylcyclohex-1-ene-1-carbaldehyde

HRID 2198586Notes

Reaction equation

HRID 2198586 reaction equation
[CH3:1][CH:2]1[C:7]([CH3:9])([CH3:8])[CH:6]([CH:10]=[O:11])[C:5]([CH3:12])=[CH:4][CH2:3]1.[OH-].[K+].[Cl-].[Na+]>CO>[CH3:1][CH:2]1[C:7]([CH3:8])([CH3:9])[C:6]([CH:10]=[O:11])=[C:5]([CH3:12])[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 14432940HCID 14432940, compound

Product 1

HCID 144329422,5,6,6-Tetramethylcyclohex-1-ene-1-carbaldehyde

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

16.6 g of 5-methyl-α-cyclocitral were added dropwise, at 0°-5° C., to a solution of 6.4 g of KOH in 110 ml of methanol, after which the reaction mixture was kept for 80 minutes at 0°-5° C. It was then poured onto 250 ml of ice water and the mixture was saturated with sodium chloride and extracted 5 times with 50 ml of ether at a time. The combined extracts were washed twice with 50 ml of saturated sodium chloride solution at a time, and were dried with anhydrous sodium sulfate.

Workup

  1. extractionextracted 5 times with 50 ml of ether at a time
  2. washThe combined extracts were washed twice with 50 ml of saturated sodium chloride solution at a time
  3. dry with materialwere dried with anhydrous sodium sulfate

Sources & evidence

ORD record
ord-7847d79ae658445f954f84a63ba9f568
Source dataset
uspto-grants-1982_11
Patent number
US04358614

Reaction notes

Loading…