Ammonia → 2-Amino-6-fluorobenzonitrile

HRID 2198689Notes

Reaction equation

HRID 2198689 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[NH3:11]>C(Cl)Cl>[NH2:11][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[C:3]=1[C:4]#[N:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 746952,6-Difluorobenzonitrile

Product 1

HCID 5226592-Amino-6-fluorobenzonitrileYield 98.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

50 parts of 2,6-difluorobenzonitrile and 40 parts by volume of ammonia are stirred for 10 hours at 100° C. in a closed vessel. The reaction mixture is taken up in methylene chloride, the solid is filtered off, the organic phase is extracted three times by shaking with water and is dried over sodium sulfate, the solvent is stripped off and the residue is dried under reduced pressure. 48 parts (98.1% of theory) of 2-amino-6-fluoro-benzonitrile, of solidification point 125°-128° C., are obtained.

Workup

  1. filtrationthe solid is filtered off
  2. extractionthe organic phase is extracted three times
  3. dry with materialis dried over sodium sulfate
  4. customthe residue is dried under reduced pressure

Sources & evidence

ORD record
ord-b8d45a9006c04cffab089aab0c8e021c
Source dataset
uspto-grants-1982_11
Patent number
US04359428

Reaction notes

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