Ammonia → 2-Amino-6-fluorobenzonitrile

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Reaction Steps

1,000 parts of 2,6-difluorobenzonitrile, 1,500 parts by volume of tetrahydrofuran and 800 parts by volume of ammonia are stirred for 10 hours at 100° C. in a closed vessel. The mixture is cooled to room temperature, the solid is filtered off and washed with tetrahydrofuran, and the organic phase is freed from solvent under reduced pressure. The residue is dried under reduced pressure. 972 parts (99% of theory) of 2-amino-6-fluorobenzonitrile, of solidification point 127° C., are obtained.

Provenance & Evidence