Ammonia → 2-Amino-6-fluorobenzonitrile

HRID 2198690Notes

Reaction equation

HRID 2198690 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](F)[C:3]=1[C:4]#[N:5].[NH3:11]>O1CCCC1>[NH2:11][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[C:3]=1[C:4]#[N:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 746952,6-Difluorobenzonitrile

Product 1

HCID 5226592-Amino-6-fluorobenzonitrileYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1,000 parts of 2,6-difluorobenzonitrile, 1,500 parts by volume of tetrahydrofuran and 800 parts by volume of ammonia are stirred for 10 hours at 100° C. in a closed vessel. The mixture is cooled to room temperature, the solid is filtered off and washed with tetrahydrofuran, and the organic phase is freed from solvent under reduced pressure. The residue is dried under reduced pressure. 972 parts (99% of theory) of 2-amino-6-fluorobenzonitrile, of solidification point 127° C., are obtained.

Workup

  1. filtrationthe solid is filtered off
  2. washwashed with tetrahydrofuran
  3. customThe residue is dried under reduced pressure

Sources & evidence

ORD record
ord-1d306feacf274cd98ea42eedd64e3198
Source dataset
uspto-grants-1982_11
Patent number
US04359428

Reaction notes

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