反应详情

t-Butyl methyl 7-bromoheptylmalonate (8.81 g, 25.1 mmol) is dissolved in acetone (50 ml). Sodium iodide (3.7 g, 25.1 mmol) is added and the mixture is stirred at reflux for 2 hours. The reaction mixture is filtered and the filtrate is concentrated to dryness. The residue is dissolved in methylene chloride and filtered again. The filtrate is concentrated to dryness to give t-butyl methyl 7-iodoheptylmalonate as an oil.

1. temperatureat reflux for 2 hours
2. filtrationThe reaction mixture is filtered
3. concentrationthe filtrate is concentrated to dryness
4. dissolutionThe residue is dissolved in methylene chloride
5. filtrationfiltered again
6. concentrationThe filtrate is concentrated to dryness