3-Fluoro-p-anisaldehyde → HCID 13059651, compound

HRID 2198825Notes

Reaction equation

HRID 2198825 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([N:9]=[CH:10][N:11]([CH3:13])[CH3:12])=[C:4]([Cl:14])[CH:3]=1.[F:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH:19]=O>CO>[Cl:14][C:4]1[CH:3]=[C:2]([N:1]=[CH:19][C:18]2[CH:21]=[CH:22][C:23]([O:24][CH3:25])=[C:16]([F:15])[CH:17]=2)[CH:7]=[C:6]([Cl:8])[C:5]=1[N:9]=[CH:10][N:11]([CH3:12])[CH3:13]

Participants

4

Reactant 2

HCID 676963-Fluoro-p-anisaldehydeHCID 13059650HCID 13059650, compound

Product 1

HCID 13059651HCID 13059651, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
5 °C

Procedure

A 7.0 g. amount of N'-(4-amino-2,6-dichlorophenyl)-N,N-dimethylformamidine and 4.6 g. of 3-fluoro-p-anisaldehyde are each dissolved separately in 25 ml. of warm methanol and then combined. The mixture is cooled at 5° C. The crystallized product is collected and washed with ether to provide 8.2 g. of the product of the Example as yellow crystals, m.p. 139°-141° C.

Workup

  1. dissolutioneach dissolved separately in 25 ml
  2. customThe crystallized product is collected
  3. washwashed with ether
  4. customto provide 8.2 g

Sources & evidence

ORD record
ord-b4284e7727ca440687c3a79442bf7e5f
Source dataset
uspto-grants-1982_11
Patent number
US04360466

Reaction notes

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