反应详情

温度

160 °C

To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.

1. additionwas added
2. temperatureThe reaction mixture was cooled
3. extractionextracted with ether
4. washThe extract was washed in water
5. distillationthe solvent was distilled off
6. customRecrystallization of the residue