HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2198840Generated: October 26, 2026
Sodium Hydroxide → 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol
https://huagongshe.com/reaction/2198840
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| Reactant | 1-Phenoxyphenol | HCID 20517352 | — |
| Product | 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol | HCID 20517315 | 58% |
Reaction Steps
To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04360464 |
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| Source dataset | uspto-grants-1982_11 |
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| ORD ID | ord-1bbc41c23d734ef6965a4c0aa24cb8cb |
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| Source note | uspto-grants-1982_11 |
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