M-Cresol → Toliprolol

HRID 2198841Notes

Reaction equation

HRID 2198841 reaction equation
[CH:1]([N:4]1[CH2:7][CH:6]([OH:8])[CH2:5]1)([CH3:3])[CH3:2].[CH:9]1[C:14]([OH:15])=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:16]>>[CH3:16][C:10]1[CH:9]=[C:14]([CH:13]=[CH:12][CH:11]=1)[O:15][CH2:5][CH:6]([OH:8])[CH2:7][NH:4][CH:1]([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 342M-CresolHCID 5446771-(Propan-2-yl)azetidin-3-ol

Product 1

HCID 18047ToliprololYield 81%

Procedure

1-(iso-propyl)-3-azetidinol and m-cresol were reacted in the same manner as in Example 6 to yield 1-(3'-methylphenoxy)-3-(iso-propylamino)-2-propanol melting at 80°-82° C. The yield was 81%.

Sources & evidence

ORD record
ord-2b89608db35f4d60951f14fb8074c153
Source dataset
uspto-grants-1982_11
Patent number
US04360464

Reaction notes

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