Ethanol → HCID 20517475, compound

HRID 2198867Notes

Reaction equation

HRID 2198867 reaction equation
[123I-].[I:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.C(O)C.[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C-:21]#[N:22].[Na+]>C(O)(=O)C.O>[NH:14]([CH:5]([C:4]1[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=1[I:2])[C:21]#[N:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

7

Reactant 4

HCID 702EthanolHCID 6115AnilineHCID 8929Sodium CyanideHCID 86738636HCID 86738636, compound

Product 1

HCID 20517475HCID 20517475, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 1 mg of I-123-o-iodobenzaldehyde prepared in accordance with example 15 in 100 mcl ethanol was placed in a small test tube. One lambda of aniline was added and the mixture allowed to stand for ten minutes. A solution of 2 mg of sodium cyanide in 10 lambda of deionized water was then added and the mixture allowed to stand for an additional ten minutes. Three lambda of acetic acid was then added and the mixture allowed to stand 20 minutes to yield α-anilino-o-iodophenylacetonitrile.

Workup

  1. customwas placed in a small test tube
  2. waitto stand for ten minutes
  3. waitto stand for an additional ten minutes

Sources & evidence

ORD record
ord-9cef9f8a8a9d4bd58e45f2dc6ef2ad11
Source dataset
uspto-grants-1982_11
Patent number
US04360511

Reaction notes

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