Choline → HCID 15580667, compound

HRID 2198984Notes

Reaction equation

HRID 2198984 reaction equation
C(O)C.OCC[N+](C)(C)C.[C:11]1([NH:17][NH2:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Cl:19][C:20]1[CH:29]=[CH:28][C:23]([CH:24]=[CH:25][C:26]#[N:27])=[CH:22][CH:21]=1>CO>[NH2:27][C:26]1[CH2:25][CH:24]([C:23]2[CH:22]=[CH:21][C:20]([Cl:19])=[CH:29][CH:28]=2)[N:17]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:18]=1

Participants

6

Reactant 4

HCID 305CholineHCID 702EthanolHCID 7516PhenylhydrazineHCID 342433-(4-Chlorophenyl)prop-2-enenitrile

Product 1

HCID 15580667HCID 15580667, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 500 ml. of absolute ethanol, 5.0 ml. of 50% choline in methanol, 32.4 g. of phenylhydrazine and 49.08 g. of p-chlorocinnamonitrile is refluxed for 7 hours then is allowed to stand at room temperature for 16 hours, then is evaporated to dryness in vacuo. The procedure of Example 16 is followed to give 12.0 g. of the product of the Example as colorless needles, m.p. 183.5°-185.5° C.

Workup

  1. additionA mixture of 500 ml
  2. customis evaporated to dryness in vacuo
  3. customto give 12.0 g

Sources & evidence

ORD record
ord-5a1866874b5743abbecb3664209c6100
Source dataset
uspto-grants-1982_11
Patent number
US04360680

Reaction notes

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