HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 5-Bromo-1-(1-methylethyl)-2-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-naphth[1,2-d]imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Citrate | HCID 31348 | — |
| Reactant | HCID 20452290 | HCID 20452290 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Bromo-1-(1-methylethyl)-2-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-naphth[1,2-d]imidazole | HCID 13806187 | — |
Reaction Steps
By following the procedure described in Example 16 but condensing 5-bromo-2-(2-chloroethyl)-1-(1-methylethyl)-1H-naphth[1,2-d]imidazole hydrochloride with 1-phenylpiperazine, the compound of the title is obtained. M.p. 211°-213° C. (from ethyl acetate). The corresponding citrate melts at 169°-171° C. with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04360674 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-67a40fdb0f984d499655b78fa010321a |
| Source note | uspto-grants-1982_11 |