1-(3-(Trifluoromethyl)phenyl)piperazine → 5-Bromo-1-(1-methylethyl)-2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1H-naphth[1,2-d]imidazole

HRID 2198992Notes

Reaction equation

HRID 2198992 reaction equation
Cl.[Br:2][C:3]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:6]2[N:7]([CH:13]([CH3:15])[CH3:14])[C:8]([CH2:10][CH2:11]Cl)=[N:9][C:5]=2[CH:4]=1.[F:22][C:23]([F:37])([F:36])[C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1>C(O)C>[Br:2][C:3]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:6]2[N:7]([CH:13]([CH3:15])[CH3:14])[C:8]([CH2:10][CH2:11][N:33]3[CH2:32][CH2:31][N:30]([C:26]4[CH:27]=[CH:28][CH:29]=[C:24]([C:23]([F:36])([F:37])[F:22])[CH:25]=4)[CH2:35][CH2:34]3)=[N:9][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 20452290HCID 20452290, compound

Product 1

HCID 138061885-Bromo-1-(1-methylethyl)-2-[2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]ethyl]-1H-naphth[1,2-d]imidazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound of the title is prepared by condensing 5-bromo-2-(2-chloroethyl)-1-(1-methylethyl)-1H-naphth[1,2-d]imidazole hydrochloride with 1-(3-trifluoromethylphenyl)piperazine. M.p. 161°-62° C. (from ethanol).

Sources & evidence

ORD record
ord-24d52891c2bf4f1cb89bf700bfee8125
Source dataset
uspto-grants-1982_11
Patent number
US04360674

Reaction notes

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