Hydrazine hydrate (1:1) → HCID 20516897, compound

HRID 2199057Notes

Reaction equation

HRID 2199057 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[C:10]([N+:17]([O-])=O)[C:9]=2[NH:20][CH3:21])=[N:6][NH:5][C:4](=[O:22])[CH2:3]1.O.NN>C(O)C.[Ni]>[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[C:10]([NH2:17])[C:9]=2[NH:20][CH3:21])=[N:6][NH:5][C:4](=[O:22])[CH2:3]1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20516911HCID 20516911, compound

Product 1

HCID 20516897HCID 20516897, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Conditions

Temperature
30 °C

Procedure

0.65 gm of 5-methyl-6-(3-nitro-4-acetyl-methylamino-phenyl)-3-oxo-4,5-dihydro-2H-pyridazine were dissolved in 30 ml of ethanol and mixed with 0.5 ml of 80% hydrazine hydrate and 0.5 gm of Raney-nickel. The reaction mixture was heated at 30° C. for 10 minutes. After filtering off of the catalyst, the filtrate was mixed with glacial acetic acid and evaporated in vacuo. The residue was directly processed further.

Workup

  1. filtrationAfter filtering off of the catalyst
  2. additionthe filtrate was mixed with glacial acetic acid
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-6450e589465149e1bb696d77c045afbc
Source dataset
uspto-grants-1982_11
Patent number
US04361563

Reaction notes

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