Hydrazine hydrate (1:1) → HCID 20516909, compound

HRID 2199063Notes

Reaction equation

HRID 2199063 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([N:14]([C:20](=[O:22])[CH3:21])[CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])=[C:10]([N+:23]([O-])=O)[CH:9]=2)=[N:6][NH:5][C:4](=[O:26])[CH2:3]1.O.NN>C(O)C.[Ni]>[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([N:14]([C:20](=[O:22])[CH3:21])[CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19])=[C:10]([NH2:23])[CH:9]=2)=[N:6][NH:5][C:4](=[O:26])[CH2:3]1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20516928HCID 20516928, compound

Product 1

HCID 20516909HCID 20516909, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

6 gm of 5-methyl-6-{3-nitro-4-[N-acetyl-N-(3-methyl-butyl)-amino]-phenyl}-4,5-dihydro-2H-pyridazine-3-one were dissolved in 150 ml of ethanol. 4 gm of Raney-nickel and 3 ml of 98% hydrazine hydrate were added, and the solution was stirred for 30 minutes at room temperature. The catalyst was filtered off, the filtrate was evaporated, and the residue was processed further without further purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. customthe residue was processed further without further purification

Sources & evidence

ORD record
ord-e2619961ab804ff3855517d50f02f970
Source dataset
uspto-grants-1982_11
Patent number
US04361563

Reaction notes

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