HCID 20516919, compound → HCID 20516926, compound

HRID 2199064Notes

Reaction equation

HRID 2199064 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:16])=[C:10]([N+:28]([O-])=O)[CH:9]=2)=[N:6][NH:5][C:4](=[O:31])[CH2:3]1.[H][H]>CN(C)C=O.[Pd]>[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[O:16])=[C:10]([NH2:28])[CH:9]=2)=[N:6][NH:5][C:4](=[O:31])[CH2:3]1

Participants

5

Reactant 2

HCID 20516919HCID 20516919, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20516926HCID 20516926, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

10 gm of 5-methyl-6-(3-nitro-4-undecane carbonylamino-phenyl)-4,5-dihydro-2H-pyridazine-3-one were dissolved in 100 ml of dimethylformamide, and the solution was treated in the presence of 1 gm of 10% palladium charcoal with hydrogen for 1.2 hours at a pressure of 5 bar. After filtering off of the catalyst, the mixture was poured on ice and extracted with methylene chloride, and the organic phase was evaporated. The oily residue was further processed directly.

Workup

  1. filtrationAfter filtering off of the catalyst
  2. additionthe mixture was poured on ice
  3. extractionextracted with methylene chloride
  4. customthe organic phase was evaporated

Sources & evidence

ORD record
ord-1351f83b2c4d43bfa51931e879b5d328
Source dataset
uspto-grants-1982_11
Patent number
US04361563

Reaction notes

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