反应详情

To 68 mg (0.33 mmol) of 2-chloro-2, 2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the above-described method, 53 mg (0.33 mmol) of 2-chloro-5-chloromethylpyridine dissolved in 6 ml of anhydrous acetonitrile was added. Subsequently, 50 mg (0.36 mmol) of potassium carbonate was added to the mixture, followed by heating under reflux for 1 hour. After completion of the reaction, the reaction liquid was returned to room temperature, and then concentrated under reduced pressure. Diethyl ether was added to the residue. As a result, a solid was precipitated. The solid was collected by filtration, and dried. Thus, the target substance was obtained. Yield: 49 mg (Percentage Yield: 45%).

1. additionwas added
2. temperatureby heating
3. temperatureunder reflux for 1 hour
4. customAfter completion of the reaction
5. customthe reaction liquid
6. customwas returned to room temperature
7. concentrationconcentrated under reduced pressure
8. additionDiethyl ether was added to the residue
9. customAs a result, a solid was precipitated
10. filtrationThe solid was collected by filtration
11. customdried
12. customThus, the target substance was obtained