2-(4'-Chlorobenzoyl)benzoic acid → HCID 58433818, compound

HRID 2199306Notes

Reaction equation

HRID 2199306 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=2[C:10]([OH:12])=O)=[O:7])=[CH:4][CH:3]=1.[CH3:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2([OH:7])[C:8]3[C:9](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:10](=[O:12])[N:26]2[CH2:25][C:24]2[CH:27]=[CH:28][C:21]([O:20][CH3:19])=[CH:22][CH:23]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 665642-(4'-Chlorobenzoyl)benzoic acidHCID 754524-Methoxybenzylamine

Product 1

HCID 58433818HCID 58433818, compoundYield 57%

Procedure

The named compound was synthesised from 2-(4-chlorobenzoyl)-benzoic acid (2.0 g, 7.6 mmol) and 4-methoxy benzylamine (0.542 mL, 4.18 mmol) using General Procedure B, purified by chromatography (Biotage SP4; 10-80% EtOAc/hexane) and obtained as a white solid (0.830 g, 57%).

Workup

  1. custompurified by chromatography (Biotage SP4; 10-80% EtOAc/hexane)

Sources & evidence

ORD record
ord-44b6c3878c1a47fe84a7adcd4cf895b4
Source dataset
uspto-grants-2016_06
Patent number
US09358222B2

Reaction notes

Loading…