Phenylacetaldehyde → HCID 117664507, compound

HRID 2199492Notes

Reaction equation

HRID 2199492 reaction equation
P(O[CH2:10][C:11]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([O:19][CH3:20])[CH:12]=1)(OCC)(OCC)=O.[C:21]1([CH2:27][CH:28]=O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:20][O:19][C:13]1[CH:12]=[C:11](/[CH:10]=[CH:28]/[CH2:27][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=1

Participants

3

Reactant 2

HCID 998PhenylacetaldehydeHCID 10828324HCID 10828324, compound

Product 1

HCID 117664507HCID 117664507, compoundYield 78%

Procedure

Use diethyl 3,5-dimethoxybenzyl phosphate and phenylacetaldehyde as materials, and follow the method described in Example 5 to obtain a pale yellow solid as the target product (78%). 1H NMR (400 MHz, DMSO-d6): 3.22 (d, J=7.6 Hz, 2H), 3.79 (s, 6H), 6.25 (s, 1H), 6.34 (d, J=16.0 Hz, 1H), 6.66 (m, 1H), 6.72 (s, 2H), 7.16 (m, 3H), 7.27 (m, 2H).

Sources & evidence

ORD record
ord-c15f7727296d41e5a676d01c4faba7e0
Source dataset
uspto-grants-2016_06
Patent number
US09359298B2

Reaction notes

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