反应详情

Cyclopropanethiol in THF/diethyl ether was admixed in portions with sodium hydride and stirred at room temperature. 1-Fluoro-4-nitrobenzene was then added in portions. The mixture was stirred for 2 hours at 40° C. After cooling, the mixture was added to water and extracted with benzene (3×). The combined organic phases were concentrated by evaporation and the residue was purified by chromatography (hexane/acetic ester 95:5). (Yield: 61%).

1. stirringThe mixture was stirred for 2 hours at 40° C
2. temperatureAfter cooling
3. extractionextracted with benzene (3×)
4. concentrationThe combined organic phases were concentrated by evaporation
5. customthe residue was purified by chromatography (hexane/acetic ester 95:5)