HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → Methyl 2-fluoro-4-{5-[2'-methoxy-2-(methoxymethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 11402049 | — |
| Reactant | 3-Methyl-4-[2-(trifluoromethyl)phenyl]benzoic acid | HCID 21947812 | — |
| Reactant | Methyl 4-{5-[4-bromo-3-(methoxymethyl)phenyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate | HCID 67528348 | — |
| Product | Methyl 2-fluoro-4-{5-[2'-methoxy-2-(methoxymethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoate | HCID 67528482 | — |
Reaction Steps
Title compound was prepared following procedure and work up described for Intermediate 5 step 2 but starting from methyl 4-{5-[4-bromo-3-(methoxymethyl)phenyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate obtained from step 1 (50 mg, 0.12 mmol) and 2-(2-methoxy-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (30.5 mg, 0.13 mmol) (130° C. for 10 min under microwave irradiation). Purification by flash chromatography (cHex:EtOAc, from 100:0 to 20:80) gave the title compound as a yellow powder. LC/MS (Method B): 449.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202865B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-d5834a286fdf49d09123732e338233a8 |
| Source note | uspto-grants-2012_06 |