反应详情

温度

80 °C

4-((1R,2R)-2-benzyloxy-1-methylpropoxy)-2-chloro-5-trifluoromethylpyrimidine and (RS)—S-(4-aminophenyl)-S-cyclopropyl-N-(trifluoroacetyl)sulphoximide in acetonitrile were admixed with a 4N solution of hydrogen chloride in dioxane and stirred for 5 hours at 80° C. After cooling, the mixture was diluted with acetic ester and washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution, dried (Na2SO4), filtered and concentrated by evaporation. The resulting residue was purified by means of chromatography (hexane/acetic ester 4:1) (yield: 56%).

1. temperatureAfter cooling
2. washwashed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated by evaporation
6. customThe resulting residue was purified by means of chromatography (hexane/acetic ester 4:1) (yield: 56%)