L-(+)-Cysteine → HCID 53800139, compound
Reaction equation
[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[OH-].[Na+].[CH2:10]1[O:12][CH2:11]1>O>[OH:12][CH2:11][CH2:10][NH:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 10 °C
Procedure
109 g (0.9 mol) of L-cysteine was added into a 2000 ml round-bottomed flask, dissolved with 1000 ml of distilled water, cooled to 10° C. in ice bath, and neutralized to PH˜7 with 24 ml of 1M NaOH solution. 100 ml of ethylene oxide which was pre-cooled was taken at 10° C. and added to the above mixture, the mixture was reacted for 1 h while keeping the temperature at 10° C., then the temperature was raised to room temperature and the reaction was continued for another 1.5 h.
Workup
- customwas taken at 10° C.
- additionadded to the above mixture
- customthe mixture was reacted for 1 h
- customat 10° C.
- temperaturethe temperature was raised to room temperature
Sources & evidence
- ORD record
- ord-7b964f29635c42e4a24e7344a0e8e296
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09359314B2
Reaction notes
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