Hydrazine hydrate (1:1) → N-tert-butyl-6-hydrazino-N-methylpyridine-3-sulfonamide

HRID 2199592Notes

Reaction equation

HRID 2199592 reaction equation
[C:1]([N:5]([CH3:16])[S:6]([C:9]1[CH:10]=[N:11][C:12](Cl)=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:18][NH2:19]>>[C:1]([N:5]([CH3:16])[S:6]([C:9]1[CH:10]=[N:11][C:12]([NH:18][NH2:19])=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86659955N-tert-butyl-6-chloro-N-methylpyridine-3-sulfonamide

Product 1

HCID 67456669N-tert-butyl-6-hydrazino-N-methylpyridine-3-sulfonamideYield 84%

Procedure

According to the process described in Example 4.2, starting with 0.66 g (2.53 mmol) of N-tert-butyl-6-chloro-N-methylpyridine-3-sulfonamide and 0.46 mL of hydrazine monohydrate, 0.55 g of N-tert-butyl-6-hydrazino-N-methylpyridine-3-sulfonamide is obtained in the form of a white solid, which is used without further purification in the following step.

Sources & evidence

ORD record
ord-645818e56d0847ff9d74bc050202aee8
Source dataset
uspto-grants-2016_06
Patent number
US09359329B2

Reaction notes

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