Morpholino(4-nitro-3-(trifluoromethyl)phenyl)methanone → (4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone

HRID 2199732Notes

Reaction equation

HRID 2199732 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([C:18]([F:21])([F:20])[F:19])[CH:10]=2)=[O:8])[CH2:3][CH2:2]1>C(O)C.[Pd]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[O:8])=[CH:10][C:11]=1[C:18]([F:21])([F:20])[F:19]

Participants

4

Reactant 1

HCID 68936908Morpholino(4-nitro-3-(trifluoromethyl)phenyl)methanone

Product 1

HCID 62155530(4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of EXAMPLE 144A (13 g) and Pd/C (1.3 g, 10%) in ethanol (300 mL) was stirred under hydrogen at room temperature for two days. The catalyst was filtered off and the solvent was evaporated to provide the final compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-607605d4353444b1a8ece2c5695ccfdf
Source dataset
uspto-grants-2016_06
Patent number
US09359296B2

Reaction notes

Loading…