HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2199744Generated: October 26, 2026
Hydrochloric Acid → 3-(7-Bromo-2-(ethoxycarbonyl)-4-fluoro-1h-indol-3-yl)propanoic acid
https://huagongshe.com/reaction/2199744
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | ethyl 7-bromo-3-(3-ethoxy-3-oxopropyl)-4-fluoro-1H-indole-2-carboxylate | HCID 68937923 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(7-Bromo-2-(ethoxycarbonyl)-4-fluoro-1h-indol-3-yl)propanoic acid | HCID 68941129 | — |
Reaction Steps
To a mixture of EXAMPLE 402A (2.3 g) in acetic acid (40 ml) was added concentrated hydrochloric acid (3 ml). The mixture was heated at 80° C. for 4 hours. After cooling to room temperature, precipitation of the product occurred. Water (50 mL) was added to further induce precipitation. The solid was filtered, rinsed with water and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09359296B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-c74e5a0c8f744890a08816e45f0c8522 |
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| Source note | uspto-grants-2016_06 |
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