Sodium Methoxide → HCID 71542527, compound

HRID 2199770Notes

Reaction equation

HRID 2199770 reaction equation
[P:1]([OH:32])([OH:31])([O:3][CH2:4][C@@H:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[N:19][C:20]([NH:23][C:24]4[N:28]([CH3:29])[N:27]=[N:26][N:25]=4)=[CH:21][CH:22]=3)=[C:13]([F:30])[CH:12]=2)[CH2:6]1)=[O:2].C[O-].[Na+:35]>CO>[Na+:35].[Na+:35].[P:1]([O-:31])([O-:32])([O:3][CH2:4][C@@H:5]1[O:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[N:19][C:20]([NH:23][C:24]4[N:28]([CH3:29])[N:27]=[N:26][N:25]=4)=[CH:21][CH:22]=3)=[C:13]([F:30])[CH:12]=2)[CH2:6]1)=[O:2]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 71542528HCID 71542528, compound

Product 1

HCID 71542527HCID 71542527, compoundYield 71.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(R)-(3-(3-fluoro-4-(6-((1-methyl-1H-tetrazol-5-yl)amino)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate (140 mg, 0.3 mmol) was dissolved in 15 mL methanol. Sodium methoxide (48 mg, 0.9 mmol) was added, and reacted at room temperature for 12 h. After filtration 110 mg of product was obtained, at a yield of 71.6%.

Workup

  1. customreacted at room temperature for 12 h
  2. filtrationAfter filtration 110 mg of product
  3. customwas obtained, at a yield of 71.6%

Sources & evidence

ORD record
ord-9e27ae68c8fa4d8a93516ce804af14b4
Source dataset
uspto-grants-2016_06
Patent number
US09359344B2

Reaction notes

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