Methanol → HCID 86729996, compound

HRID 2199773Notes

Reaction equation

HRID 2199773 reaction equation
[CH3:1][O:2][CH2:3][N:4]1[CH:8]=[C:7]([N+:9]([O-])=O)[N:6]=[N:5]1.[Cl-].[NH4+].CO>[Zn].O1CCCC1>[CH3:1][O:2][CH2:3][N:4]1[CH:8]=[C:7]([NH2:9])[N:6]=[N:5]1

Participants

6

Reactant 3

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 86729995HCID 86729995, compound

Product 1

HCID 86729996HCID 86729996, compoundYield 79.6%

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 8028TetrahydrofuranSolvent

Procedure

1-(methoxymethyl)-4-nitro-1H-1,2,3-triazole (5.517 g, 34.891 mmol), zinc powder (22.697 g, 349.185 mmol) and ammonium chloride (18.678 g, 349.187 mmol) were added successively into a mixed solvent of methanol (100 mL) and tetrahydrofuran (100 mL), and stirred for 18 hours. The insoluble was removed by suction filtration. After concentration, 1-(methoxymethyl)-4-amino-1H-1,2,3-triazole was obtained as 3.56 g of a brown-yellow oil, at a yield of 79.6%.

Workup

  1. customThe insoluble was removed by suction filtration
  2. concentrationAfter concentration

Sources & evidence

ORD record
ord-95824bb38cd7447eb7f64173621ace1d
Source dataset
uspto-grants-2016_06
Patent number
US09359344B2

Reaction notes

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