3-(Trifluoromethyl)benzyl chloride → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199936Notes

Reaction equation

HRID 2199936 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]Cl.[CH2:13]([N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][C:30]([OH:32])=[O:31])[CH:27]=2)[CH:22]=[CH:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][C:30]([OH:32])=[O:31])[CH:27]=2)[CH:22]=[CH:21]1.[CH2:13]([N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][C:30]([OH:32])=[O:31])[CH:27]=2)[CH:22]=[CH:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 697163-(Trifluoromethyl)benzyl chlorideHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184353HCID 68184353, compound

Procedure

The titled compound (38 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 3-(trifluoromethyl)benzyl chloride according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-e7d377cbd5604ccbadc77e17ef73bd0e
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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